3. Sao Paulo (Brazil)
Slowly but steadily, we have come to the largest Brazilian and South American city. Sao Paulo is 40th in the world by expensiveness according to Mercer’s 2015 cost of living report. It used to be 49th a year before, and its combined CPI, groceries and restaurant index amounts to 55.14, according to Numbeo’s 2015 report.