6. Ehlers-Danlos Syndrome
Halfway on our list of most interesting and extremely rare genetic disorders is Ehlers-Danlos Syndrome. The subdivisions of this disorder are arthrochalasia type, cardiac valvular form, classic type, dermatosparaxis type, hypermobility type, kyphoscoliotic type, progeroid form, and vascular type. EDS symptoms depend on what subtype the person has, but they can range from chronic joint pain to fragility of the skin.