7. Marfan Syndrome
A serious aortic enlargement could be a sign of Marfan Syndrome. Marfan syndrome can be inherited but there are instances where this occurs for the first time in a family. This syndrome affects the connective tissue of the body, so it can affect a variety of different body parts. About 1 in 5,000 people have Marfan Syndrome, so it is more common than you think.